Relaxant effects of selected sildenafil analogues in the rat aorta
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چکیده
منابع مشابه
The Effects of Topical Sildenafil on Wound Healing in Rat
Nitric oxide (NO) is an important molecule synthesized during wound repair. Studies have reported the use of NO donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. The aim of this work was to investigate the effects of topical sildenafil on wounds in rats. Sildenafil (25 mg) was topically applied once daily on wound in treatment groups. On...
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متن کاملDifferential effects of the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil in rat aorta.
Presumably, the vasorelaxant properties of phosphodiesterase type 5 (PDE5) inhibitors are similar in isolated blood vessels. We aimed to explore the mechanisms underlying the vasorelaxation induced by the selective PDE5 inhibitors sildenafil, vardenafil, and tadalafil in the rat aorta. Aortic rings were mounted in 5-ml organ baths, and concentration-response curves for PDE5 inhibitors (0.0001-1...
متن کاملthe effects of topical sildenafil on wound healing in rat
nitric oxide (no) is an important molecule synthesized during wound repair. studies have reported the use of no donors on cutaneous wound repair, but their effects in different phases of healing are not elucidated. the aim of this work was to investigate the effects of topical sildenafil on wounds in rats. sildenafil (25 mg) was topically applied once daily on wound in treatment groups. on days...
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ژورنال
عنوان ژورنال: Journal of Enzyme Inhibition and Medicinal Chemistry
سال: 2015
ISSN: 1475-6366,1475-6374
DOI: 10.3109/14756366.2015.1024674